Jobs

 

SECRET

European Training Network

15 PhD Student positions

4 PhD positions – call for applications

Applications are invited from candidates of excellence wishing to pursue a PhD degree in the field of cancer cell biology or computational biology. Students will receive training within a pan-European academic/private sector research training network, specifically focused on breast and colorectal cancer research. Please see the project descriptions below for further information.

Required documents: a full CV, BSc and MSc transcripts, a motivation letter including a description of previous research experiences and contact details or recommendation letters of two 2 referees. In case of project 2.7, your MSc thesis is also required. Only documents in English will be accepted.

Submission: Applicants should submit the documentation to SECRET@izi.uni-stuttgart.de, writing on the subject line the number of project (Project 1.4, Project 1.8, Project 2.3 or Project 2.7) by January 12th, 11:00 PM (CET).

Each Early Stage Researcher (ESR) within SECRET-ITN will be the driving force of an Individual Research Project (IRP), to be completed within 3 years. The ERS will be hosted in one of the beneficiaries’ labs, and will have the opportunity to complement his/her work with at least two secondments within beneficiary or partner institutions.

Eligibility

Who can apply?

Applicants shall, at the time of recruitment by the host organisation, be in the first four years (full-time equivalent research experience) of their research careers and not yet have been awarded a doctoral degree.

Full-Time Equivalent Research Experience is measured from the date when a researcher obtained the degree which would formally entitle him/her to embark on a doctorate.

Mobility Rule: at the time of recruitment by the host organisation, researchers must not have resided or carried out their main activity (work, studies, etc.) in the country of their host organisation (either Israel or Italy, depending on the project) for more than 12 months in the 3 years immediately prior to the recruitment date*. Compulsory national service and/or short stays such as holidays are not taken into account.

Secondments: The recruited researchers will be seconded to other beneficiaries and/or to partner organisations for duration of up to 30% of their recruitment period. Normal practice during secondments is for the researchers to keep their contract with the sending institution, which also pays their travel and subsistence expenses (e.g. accommodation). During their secondment, researchers receive supervision and training at the premises of the receiving beneficiary or partner organisation.

* recruitment date = the start date of the work


Job openings at a glance:

Work Package 1 – Mechanisms

IRP 1.4 – Systematic analysis of the role of Golgi fragmentation in TNBC progression

IRP 1.8 – Links between the autoregulation of cargo export from the ER and the control of TNBC cell growth

Work Package 2 – Biomarkers

IRP 2.3 – Data science and systems biology approaches to derive biological insights from secretome data sets

IRP 2.7 – Development of a method and tools to predict drug targets for cancer within the secretory pathway


IRP 1.4 – Systematic analysis of the role of Golgi fragmentation in TNBC progression

Project description:

The candidate will address the question of why breast cancer cells exhibit a fragmentation of the Golgi apparatus and what advantage this condition confers to the cancer cells. This will be addressed using a combination of live cell imaging and siRNA screening. 

Skills and Qualifications:

· The candidate should have a master degree in life sciences (Biology, Medicine, Pharmacy, or equivalent). 

· Experience with microscopy techniques is highly desired. Any further experience with membrane traffic would be advantageous.  

· 3 year duration

Location: University of Oslo, Norway

Principal Investigator: Prof Hesso Farhan (UiO)

Collaborators: Prof Christian Behrends, Ludwig- Maximilian-University Munich, Germany (LMU); Prof Roded Sharan, Tel Aviv University, Israel (TAU); and Dr. Julia Schüler, Charles River Discovery Services, Germany (CRDS)

 

IRP 1.8 – Links between the autoregulation of cargo export from the ER and the control of TNBC cell growth

Project description:

The secretory pathway responds to signals induced by the availability of environmental factors such as nutrients and growth factors. However, little is known about autochthonous regulation of the secretory pathway by signalling molecules. A recently uncovered signaling complex named AREX (Autoregulation of endoplasmic Reticulum EXport) exerts a positive regulatory action on the ER export machinery, effectively coupling protein folding with the ER export process. The candidate will characterize autoregulatory signalling at the ER-Golgi interface and explore its role in TNBC progression in 3D cell culture models and in vivo

Skills and Qualifications:

· The candidate should have a master degree in life sciences (Biology, Medicine, Pharmacy, or equivalent) and have a background in the fields of cell biology, biochemistry or related disciplines. Experience in cell culture and microscopy techniques is an advantage.

· 3 year duration

Location: National Research Council of Italy, Naples 

Principal Investigator: Prof Alberto Luini (CNR)

Collaborators: Dr Julia Schüler, Charles River Discovery Services, Germany (CRDS) and Dr Helmut Dolznig, Medical University Vienna, Austria (MUW)

 

IRP 2.3 – Data science and systems biology approaches to derive biological insights from secretome data sets

Project description:

The project will combine the results of statistical analyses in a manner that incorporates the known complementarity of the underlying biological functions. The ESR will develop semi-automated, iterative processes that can be optimized around a metric of biomarker quality to screen different data sets. This approaches will be applied with the aim of identifying relevant cross-talks between the measured secreted factors and key molecular players in cancer and identify new potential points of monitoring or therapeutic intervention.

Skills and Qualifications:

· The candidate should hold a Master`s degree or equivalent and a strong background in bioinformatics, computer science, mathematics, physics or similar with a strong interest in molecular biology

· Experience programming in Matlab and/or Python

· Basic statistical knowledge and/or experience with R

· Fluent spoken and written English skills

In addition, the following experience would be helpful, but not essential:

· Experience in systems biology or systems medicine.

Location: Anaxomics Biotech S.L., Spain

Principal Investigators: The candidate will be directed within Anaxomics by Dr. Judith Farrés and Dr. José Manuel Mas and enrolled in the PhD program on Bioinformatics at Universitat Autònoma de Barcelona and be co-directed by Prof. Xavier Daura (AX)

Collaborators: Prof Connie Jimenez, VU University Medical Center, The Netherlands (VUmc) and Prof Xavier Daura, University Autonoma de Barcelona, Spain (UAB)

 

IRP 2.7 – Development of a method and tools to predict drug targets for cancer within the secretory pathway

Project description:

Cell proliferation requires an increased rate of protein synthesis and need to sort and secrete those proteins through the secretory pathway. Understanding secretory pathway regulation is thus a basis for the development of therapeutic strategies targeting secretion and thus aberrant cancer proliferation. The goal of this project is to develop and validate a systems-biology-based tool that can predict druggable secretory pathway proteins in cancer by combining combinatorial optimization and machine learning techniques.

Skills and Qualifications:

· The candidate should hold an MSc with thesis in computer science or related disciplines. 

· 3 year duration

Location: Tel Aviv University, Israel

Principal Investigator: Prof. Roded Sharan (TAU)

Collaborators: Prof Hesso Farhan, University of Oslo, Norway (UiO) and Prof. Tilman Brummer, University Medical Center Freiburg, Germany (UKLFR)