Publications

In order to optimise the impact and re-use of publicly funded scientific research, H2020 programs require exclusively open access publications. The benefits of such an approach are extensive, including better and more efficient science, economic growth, and broader, faster, more transparent and equal access for the benefit of researchers, industry and citizens in the EU and beyond. For more details, take a look at the Open Access Policies and Requirements in Horizon 2020.

2025

Research article: by 
Juan Manuel García-Illarramendi, Pedro Matos-Filipe, Jose Manuel Mas, Judith Farrés and Xavier Daura 

Digital patient modeling identifies predictive biomarkers of regorafenib response in elderly metastatic colorectal cancer


Front. Syst. Biol., 2025

doi: 10.3389/fsysb.2025.1648559


Research article: by Elena Gutiérrez-Galindo ∙ Katharina Jursik ∙ Yannick Frey ∙ Florian Meyer ∙ Angelika Hausser

PKD3 localizes to late endosomes to maintain Rab7-dependent endolysosomal homeostasis


iScience. 2025

doi: 10.1016/j.isci.2025.113408 

Highlights

• Endogenous PKD3 localizes to membranes of the endolysosomal compartment.

• PKD3 maintains Rab7 and retromer recruitment to late endosomes.

• PKD3 loss results in impaired lysosomal acidification.

• PKD3 function supports Wnt signalling to promote breast cancer stemness.


Research article: by Sebastian Höpfl, Merih Özverin, Helena Nowack, Raluca Tamas, Andrew G. Clark, Nicole Radde, Monilola A. Olayioye

Integrated mathematical and experimental modeling uncovers enhanced EMT plasticity upon loss of the DLC1 tumor suppressor


PLOS Comp Biol 2025

doi: 10.1371/journal.pcbi.1013076


2024

Research article: by Gali, A., Bijnsdorp, I.V., Piersma, S.R., Pham, T.V., Gutiérrez-Galindo, E., Kühnel, F., Tsolakos, N., Jimenez, C.R., Hausser, A., Alexopoulos, L.G.

Protein Kinase D drives the secretion of invasion mediators in triple-negative breast cancer cell lines


iScience. 2024

doi: 10.1016/j.isci.2024.108958


2023

Research article: by Bersano J, Lashuk K, Edinger A, Schueler J.

A Subset of Colon Cancer Cell Lines Displays a Cytokine Profile Linked to Angiogenesis, EMT and Invasion Which Is Modulated by the Culture Conditions In Vitro


Cells. 2023; 12(21):2539.

doi: 10.3390/cells12212539


Review article: by Gutiérrez-Galindo E, Yilmaz ZH and Hausser A

Membrane trafficking in breast cancer progression: Protein Kinase D comes into play


Front. Cell Dev. Biol., 2023, 11:1173387.

doi: 10.3389/fcell.2023.1173387


Research article: by Atanasova VS, de Jesus Cardona C, Hejret V, Tiefenbacher A, Mair T, Tran L, Pfneissl J, Draganić K, Binder C, Kabiljo J, Clement J, Woeran K, Neudert B, Wohlhaupter S, Haase A, Domazet S, Hengstschläger M, Mitterhauser M, Müllauer L,Tichý B, Bergmann M, Schweikert G, Hartl M, Dolznig H, Egger G.

Mimicking Tumour Cell Heterogeneity of Colorectal Cancer in a Patient-derived Organoid-fibroblast Model” . Cell Mol Gastroenterol Hepatol. 2023 Mar 2: S2352-345X(23)00036-X.


Research article: by Junet V, Matos-Filipe P, García-Illarramendi JM, Ramírez E, Oliva B, Farrés J, Daura X, Mas JM, Morales R.

A decision support system based on artificial intelligence and systems biology for the simulation of pancreatic cancer patient status“. CPT Pharmacometrics Syst Pharmacol. 2023; 00: 1- 13.

doi:10.1002/psp4.12961


2022

Research article: by Likonen, D., Pinchasi, M., Beery, E., Sharan, R., Gervits, A., Signorini, L., Lahav, M., Raanani, P., Uziel, O., (2022), “Exosomal telomerase transcripts reprogram the microRNA transcriptome profile of fibroblasts and partially contribute to CAF formation“. Sci Rep 12, 16415.

doi: 10.1038/s41598-022-20186-8


Research article: by Santosh Phuyal, Elena Djaerff, Anabel-Lise Le Roux, Martin J Baker, Daniela Fankhauser, Sayyed Jalil Mahdizadeh, Veronika Reiterer, Amirabbas Parizadeh, Edward Felder, Jennifer C Kahlhofer, David Teis, Marcelo G Kazanietz, Stephan Geley, Leif Eriksson, Pere Roca-Cusachs & Hesso Farhan

Mechanical strain stimulates COPII-dependent secretory trafficking via Rac1” in The EMBO Journal, 2022

doi: 10.15252/embj.2022110596


Review article: by Simona Del Giudice, Valentina De Luca, Seyedehnegar Parizadeh, Domenico Russo, Alberto Luini and Rosaria Di Martino,

Endogenous and Exogenous Regulatory Signaling in the Secretory Pathway: Role of Golgi Signaling Molecules in Cancer” in Frontiers in Cell and Developmental Biology  2022,  10:833663

doi: 10.3389/fcell.2022.833663


Review article: Liccardo F, Luini A, Di Martino R

Endomembrane-Based Signaling by GPCRs and G-ProteinsCells. 2022; 11(3):528.

https://doi.org/10.3390/cells11030528


2021

Review article: by Jessica Karta, Ysaline Bossicard, Konstantinos Kotzamanis, Helmut Dolznig  and Elisabeth Letellier, Mapping the Metabolic Networks of Tumor Cells and Cancer-Associated Fibroblasts” in the Special Issue Targeting Tumour Metabolism for Cancer Therapy in Cells 202110(2), 304

 https://doi.org/10.3390/cells10020304


Ghannoum, S., Leoncio Netto, W., Fantini, D., Ragan-Kelley, B., Parizadeh, A., Jonasson, E., Ståhlberg, A., Farhan, H., & Köhn-Luque, A. (2021). DIscBIO: A User-Friendly Pipeline for Biomarker Discovery in Single-Cell TranscriptomicsInternational journal of molecular sciences22(3), 1399. https://doi.org/10.3390/ijms22031399


Research article: Signorini, L.F., Almozlino, T. & Sharan, R. ANAT 3.0: a framework for elucidating functional protein subnetworks using graph-theoretic and machine learning approaches” in BMC Bioinformatics 22, 526 (2021).

https://doi.org/10.1186/s12859-021-04449-1

 


2019

Review article: Monilola A. Olayioye, Bettina Noll and Angelika Hausser, Spatiotemporal control of intracellular membrane trafficking by Rho GTPases” in the Special Issue “Membrane Traffic in Health and Disease” in Cells 20198(12), 1478; 

https://doi.org/10.3390/cells8121478.